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Vasiliy Ustinov
Vasiliy Ustinov

Manara - The Licensing Machine



With campuses located in Arlington and Irving and its district office located at 8113 Ridgepoint Drive, Suite 202 in Irving, Manara Academy District is a top-rated, public charter school district with three campuses: Arlington STEM Academy, Irving Elementary and Learning Academy in Irving. As one of the most diverse schools in Texas, the district has a Superior "A: rating from Charter FIRST and a "B" rating from the Texas Education Association. The Superintendent is Denise Sudan and Board Members are Dr. Ehap Sabri, Sadak Shaikh, Dr. Ali Shaqlaih, Jaszeer Mohammed, Brandy Schott, and Iyad Al-Nachef. For more information about enrollment, career opportunities, or school programs, visit www.manaraacademy.org




Manara - The Licensing Machine


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Sometimes the collected time series may be corrupted, incomplete and/or subjected to the sensors' errors because of the remoteness of the historic building location, the natural aging of the sensor or the lack of a continuous check of the data downloading process. For this reason, in this work, an innovative approach about reconstructing the indoor microclimate into heritage buildings, just knowing the outdoor one, is proposed. This methodology is based on using machine learning tools known as variational auto encoders (VAEs), that are able to reconstruct time series and/or to fill data gaps.


The novelty of this work is discussed in the framework of the existing literature. The work explores the potentials of machine learning tools compared to traditional ones, providing a method that is able to reliably fill missing data in time series.


The third approach (Han et al., 2021), through an initial pre-processing and augmentation of the data, makes it possible to build a sufficiently large dataset to feed a machine learning algorithm able to model the system, including its stochastic parts. In this way, good use is made of both clean and spoiled data, which still carry meaningful information and should not thus be simply discarded. Even though the pre-processing phase makes this approach less generalizable to other kind of tasks, it seems to be the only way to tackle a problem with high stochasticity and low data availability. However, in literature the focus is on the forecast of a single measurement, given its history (Arslan and Sekertekin, 2019; Han et al., 2021).


Having defined the TE score, it is possible to go on with the definition of the VAEs. A VAE (Goodfellow et al., 2016; Mehta et al., 2019) is an unsupervised machine learning model that is able to learn and approximate the probability distribution of training data, allowing then the sampling of newly generated data. The architecture is made of three main components: the encoder, the bottleneck and the decoder. The encoder is a neural network in charge of compressing the input data into a low-dimensional representation. In the present setting, this representation consists of the mean and variance vectors of a symmetric multinomial Gaussian, which represents the probability distribution of the latent variables, z. The dimensionality of the latent space is a hyper parameter to be tuned, and it corresponds to the amount of information that has to be retained from the input data. In the bottleneck, it is possible to sample latent variables and feed them into the decoder neural network, which produces in output a sample resembling the original data.


In this work an attempt to implement an unsupervised machine learning method for the problem of reconstructing the internal climate time series of a heritage building, a stave church in this case, has been proposed. As previously underlined, there are some criticalities within this approach, which are due to the poor amount of available data.


With its district location at 8113 Ridgewood Drive, Suite 202 in Irving, Manara Academy District is a top-rated, public charter school district. As one of the most diversity supporting schools offering project-based learning and foreign language programming in Texas, the district has a Superior "A" rating from Charter FIRST and a "B" rating from the Texas Education Association. The Superintendent is Denise Sudan and Board Members are Dr. Ehap Sabri, Sadak Shaikh, Dr. Ali Shaqlaih, Jaszeer Mohammed, Brandy Schott, and Iyad Al-Nachef. For more information about enrollment, career opportunities, or school programs, visit www.manaraacademy.org.


  • Beckhoff does not test the operation of TwinCAT software on virtual machines and therefore cannot guarantee its functionality in this environment.

  • The use of TwinCAT software on virtual machines is at your own risk.

  • Beckhoff does not provide support for specific problems when using the TwinCAT software on virtual machines.



Tests can only check the functionality in a current state of the VM. You cannot guarantee hard real time in any given state of a VM. Applications for which hard real time is critical (such as machine controls), should therefore not be run on a VM.


  • Especially for questions regarding the change of the licensing basis, the Beckhoff Service is available.Please refer to the corresponding subitem on this page.

  • Especially for support with questions about the TwinCAT License Server (tclicense@beckhoff.com) the email address support.tclicense@beckhoff.com is also available.



Innovative approaches for the perfusion of organs recovered for transplantation are underway by ex situ (outside the body) machine perfusion of individual deceased donor organs and in situ (inside the body) regional perfusion of thoracic and abdominal organs in the deceased donor (see the Algorithm Fig. 1). Appropriate post-transplant outcomes have been accomplished with cDCDD kidneys and lungs without the necessity of dynamic perfusion strategies. Hence, developing countries need not presume that sophisticated preservation technology is a requirement for successful cDCDD kidney transplantation. Nevertheless, strategies of perfusion and repair are essential for cDCDD liver transplantation because of the complications that occur following cold storage of the liver, and to make cDCDD heart transplantation possible.


Normothermic ex situ lung perfusion was clinically introduced as a platform to preserve, assess and recondition lungs after recovery from the donor prior to transplantation [66, 67]. This technique was originally pioneered by Stig Steen (Lund, Sweden) [68] and further developed by the Toronto group as a clinical tool to (re)evaluate the function of the pulmonary allograft that may have suffered considerable injury during the process of organ donation [69, 70]. Several commercial devices for machine lung perfusion are currently available [71].


TA-NRP is being used in the UK, Belgium, and more recently in Spain as a strategy to allow the validation and preservation of hearts of cDCDD donors [63, 83,84,85,86]. In the British experience, most hearts recovered by using TA-NRP have been followed by ex situ machine perfusion. Eight heart transplant procedures have taken place in the world with the use of TA-NRP without ex situ machine perfusion. Given the high cost of ex situ machine perfusion, unaffordable in many settings, TA-NRP may become a way of making heart transplantation from cDCDD donors economically feasible in some countries.


SK is a co-founder of Perfusix Canada (PXCA). This company provides ex situ lung perfusion (EVLP) services and training to University Health Network. Due to conflict of interest relative to EVLP activities as lung transplant surgeons in the institution, SK does not receive any payments from PXCA. Furthermore, with respect to the provision of EVLP services, PXCA is a non-profit company that does not generate profit from EVLP activities provided for UHN patients. SK is a co- founders of XOR Labs Toronto (XOR), a company dedicated to development of EVLP machines. The XOR EVLP machine is in development phase and has not been used in any patients reported on in this manuscript. Lung Bioengineering (LBI), a subsidiary of United Therapeutics, acquired Perfusix USA in 2015, a company that was co-founded by SK. Currently SK is a paid consultant for LBI. He provides strategic advice to LBI lung perfusion center as a member of its Scientific Advisory Board. DVR was a principal investigator in the Inspire and Expand trial sponsored by Transmedics, Inc (Andover, MA, USA). He received travel reimbursement to attend scientific advisory board meetings organized by Transmedics. The rest of the authors declare no conflicts of interest.


The Manara Harmonic Scanner uses advanced algorithms and machine learning techniques to scan the market for potential trading opportunities. Once a setup is identified, the software calculates the risk to reward ratio and presents the information to the user. From there, the user can decide whether or not to enter the trade based on their own analysis and risk tolerance.


Cold air inhaled by hockey players increases the amount of inflammatory cells (granulocytes and macrophages) in the respiratory tract (Larsson et al., 1998). Moreover, hockey players are in contact with carbon monoxide, nitrogen monoxide and nitrogen dioxide contained in the air of sports facilities (produced by ice cleaning machines). A study conducted by Thunqvist et al. (2002) showed that children playing hockey in facilities with an increased N2O content (mean concentration 510 ug/m3) more often suffered from symptoms of rhinitis and wheezing respiration in comparison with children playing in facilities where the concentration of this gas was low (mean 89 ug/m3). 041b061a72


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